Developing a predictive exposomic risk score for non-communicable diseases
ENACT investigates how environmental factors, exposure levels, and individual vulnerabilities interact to influence the risk of hospitalisation for both chronic and acute non-communicable diseases (NCDs).
Using retrospective health data from Belgium, ENACT will develop an exposomic risk prediction model focused on NCD-related hospitalisations. This model will be validated and calibrated with retrospective data from five national cohorts across Belgium, Bulgaria, Ireland, Italy, and Spain.
To personalise risk assessment, the population-level model will be adapted by integrating data from healthy volunteers in five pilot cities—Brussels, Sofia, Waterford, Turin, and Madrid—using environmental and biomonitoring sensors specifically developed within the ENACT project.
The pilot studies will enhance the model’s accuracy and generalisability by addressing different populations (adults and children), environmental stressors (such as air pollution, noise, and light), and diverse health outcomes, including acute and chronic vascular and non-vascular diseases, as well as dermatological, ocular, and respiratory conditions.
ENACT seeks to empower citizens, healthcare professionals, and policymakers with actionable tools, robust data, and scientific insights to support informed decision-making on environmental health. The project contributes to the EU’s public health strategies and sustainability objectives.
